The Family Gene: A Mission to Turn My Deadly Inheritance into a Hopeful Future

The Family Gene A Mission to Turn My Deadly Inheritance into a Hopeful Future A riveting medical mystery about a young woman s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicineWhen Joselin Linder

  • Title: The Family Gene: A Mission to Turn My Deadly Inheritance into a Hopeful Future
  • Author: Joselin Linder
  • ISBN: 9780062378897
  • Page: 483
  • Format: Hardcover
  • A riveting medical mystery about a young woman s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicineWhen Joselin Linder was in her twenties her legs suddenly started to swell After years of misdiagnoses, doctors discovered a deadly blockage in her liver Struggling to find an explanation forA riveting medical mystery about a young woman s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicineWhen Joselin Linder was in her twenties her legs suddenly started to swell After years of misdiagnoses, doctors discovered a deadly blockage in her liver Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father who had died from a mysterious disease, ten years prior with that of an uncle who had died under similarly strange circumstances Delving further into the past, she discovered that her great grandmother had displayed symptoms similar to hers before her death Clearly, this was than a fluke Setting out to build a complete picture of the illness that haunted her family, Joselin approached Dr Christine Seidman, the head of a group of world class genetic researchers at Harvard Medical School, for help Dr Seidman had been working on her family s case for twenty years and had finally confirmed that fourteen of Joselin s relatives carried something called a private mutation meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation Here, Joselin tells the story of their gene the lives it claimed and the future of genomic medicine with the potential to save those that remain Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write an exploration of family, history, and love.
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      483 Joselin Linder
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      Posted by:Joselin Linder
      Published :2018-08-25T10:56:35+00:00

    935 Comment

    • Rebecca Foster says:

      (3.5) My eye was drawn to The Family Gene because of the medical mystery aspect: 14 members of Linder’s Ashkenazi Jewish family are the only known exemplars of their particular genetic disease, so rare it doesn’t have a name or surefire treatment protocol, but now at least has a location on a chromosome.Linder’s awareness of her family’s peculiar medical problems began when her father, William, himself a doctor near their home in Columbus, Ohio, started having a persistent build-up of ly [...]

    • Jessica says:

      When Joselin Linder was a teenager in the late 80s, her father grew ill. His symptoms—primarily, that his body was swelling and his lungs were filling with fluid leaking out of his lymphatic system—confounded doctors, as they didn't seem to align with any known condition. There seemed to be no discernible reason for this to be happening to an otherwise healthy, middle-aged man. And there seemed to be no way to treat his symptoms. But some older relatives recognized the symptoms: they were th [...]

    • Barbara (The Bibliophage) says:

      The Family Gene by Joselin Linder is everything I wish for in a medically-oriented memoir. Linder blends the science of genetics deftly with her own family’s story. It was so compelling that I flew through the book in just a day or so.When Joselin is just fifteen, she and her family begin to watch her father die a slow, painful and frankly horrific death. He literally never received a diagnosis for this fatal disease. The family begins to realize that his condition was very similar to two othe [...]

    • Marika says:

      A compelling medical mystery that involves a faulty gene that is inherited. The author's legs began to swell when she was in her early 20's and the medical profession was stumped as to the cause. So began Joselin's journey to decipher what is truly going on. She begins by reviewing her father's medical chart (he was a physician) as to what caused his death. This is a true medical detective book that will leave readers cheering and hoping for Joselin and wondering about their relatives that died [...]

    • Caidyn (BW Book Reviews; he/him/his) says:

      This review and others can be found on BW Book Reviews.This book took me a long time to listen to because it was interrupted by my finals. No work means no listening to books. Even though it was good, I couldn't listen to it on my free time thanks to being a responsible college student and doing this dreadful thing called "studying". Warn your kids about it. It can get pretty terrifying.As I said, this was a good book. It was fun and I really enjoyed how it was read. Just very upbeat and light m [...]

    • Jessica Howard says:

      FASCINATING. I couldn't put this down. An intriguingly sad mix of science, genetics, and family tragedies.

    • Phil says:

      I was pulling into the parking lot of the supermarket where I shop, listening to NPR. The interview with Ms. Linder that was so fascinating, so interesting, I sat in the parking lot until the interview ended. And I promptly ordered the book. I have a potentially fatal genetic disorder, but at 72 I do not give it much thought. I know of no one in my family history who had it. (But could it have been properly diagnosed?)Is my case a "one-off," a one time thing? Am I the first documented case in my [...]

    • Jessica Mannion says:

      Joselin Linder's “The Family Gene” is the incredibly moving story of one woman's quest to understand the deadly genetic disease that has plagued her family for several generations. But, in spite of its tragic subject-matter, this book is ultimately about hope. As a writer, reporter, and self-professed science-nerd, Linder shares both personal and family stories generously, while simultaneously chronicling the decades long search of medical professionals struggling to understand and treat her [...]

    • Julie says:

      Joselin Linder writes a book that is one half memoir and another medical mystery. She describes watching her physician father become more and more unwell, while doctors struggle to figure out what is wrong with him. It is not until other family members succumb to the same symptoms and problems, that the family and doctors begin to realize that this disease that only affects their family has a genetic cause. With advances in genetic testing many of the family bring themselves forward to be tested [...]

    • Patricia Farley says:

      This was the first book I've won in a contest and it was fantastic! I finished it very quickly as it was hard to put down. The book starts off with her dad dying from a mysterious illness which is from a gene passed down through an X chromosome. There are many scientific and medical terms used throughout this book but these terms are explained so they are easily understood. Ms Linder is also found to have this gene and is very honest about what is happening to her and the members of her family. [...]

    • Miriam says:

      This is the tale of searching for a cure for a rare or "orphan" disease. Lindner's family is dying from mysterious causes. She traces her family tree and finds several other deaths like her father's. Part investigation, part medicine, Linder teaches readers about genetic testing and gene therapy. You could compare this with The Immortal Life of Henrietta Lacks" with much more science thrown in.The book is sad and uplifting t the same time. Be forewarned, reading this at night may keep you up unt [...]

    • Esther Bradley-detally says:

      My last two review disappeared into the ether; this is an excellent book; fraught with horror, courage, tension, maturity, bravery, and deals with current issues. Genetic diseases are cropping up with extreme rapidity, and many are not known about; highly recommend book

    • Kirsten Kinnell says:

      Incredibly compelling as both a medical mystery and a memoir. Lovely writing that makes complicated science accessible, and a voice that by turns is hilarious and heart breaking.

    • Pamela DiFrancesco says:

      This book is part medical mystery, part memoir, and all page-turner. Joselin Linder writes with such obvious skill, humor, and talent. Her thoughts on the life-threatening genetic mutation that her family is a founder population for and life in general make this one-of-a-kind book even more fascinating and readable. It's an amazing story, and in the hands of a brilliant writer like Linder, the science and medicine of it come to life with wit and humor and kindness.

    • Janis Mills says:

      It takes a certain amount of courage to know how you are going to die according to my belief. The author wrote of her gene pool and the effort and heartache to track down the disease taking family members too young. It was a fascinating story told with courage.

    • Cynthia says:

      Very interesting and well written! I love medical-mystery nonfiction!

    • Jo says:

      Well written and interesting, but the medical stuff was a little gross and deeply detailed for my taste though I guess I should have expected that going into it. It was a fascinating story of how they are trying to determine the genetic issues that are causing the illnesses in her family.

    • Donna P says:

      I loved reading this book! I'm always fascinated by medical mysteries and dramas. The author took me on the tragic, yet fascinating, story of a gene apparently found nowhere else in the world but her family. We get the personal stories of family members (with and without the gene), the genetics behind the whole thing, and the slew of diseases and conditions caused by this tiny mutation.If you enjoy medical stories, you must read this book.

    • Miriam says:

      I cannot recommend this book highly enough. This true tale of the author's family's genetic anomaly and the search for a cure had me enthralled from the first page to the last. Seriously, I lost sleep due to not being able to put the book down. If you're interested in genetics, like medical mysteries, or just enjoy a good read, pick up this book right now. You won't be disappointed.

    • Jen says:

      I am not generally a reader of nonfiction, so it means alot when I say this was a page-turner.Part memoir, part love letter to her dad and part genetics lesson--it was just amazing.You will laugh a lot and you will learn a lot. Enjoy.

    • Prakash Nepal says:

      A compelling story of a family haunted by an erroneous gene that trailed many generations with suffering and uncertainty. The scientific aspect of gene and its role is presented well for those who may not be familiar with it, but even to those readers who know the science of gene and its mechanisms, this book adds the tangible impact of a gene to humanity. The author’s shift of perspective on death as she moves from her rebellious youthful years to adulthood was insightful and inspiring. Often [...]

    • Rosanna says:

      What would you do if you knew you had a genetic predisposition for a horrible, painful disease that would lead to death in a short amount of time? In recent years, there have been several advances in the genomics field that allow people to find out this information. If you find out, then what do you do with it?This story is about a young woman whose great-grandmother, uncle, and father all develop very similar symptoms and then die a painful, uncomfortable death. After years of putting pieces to [...]

    • Jon says:

      I've always been interested in genetics for many different reasons including just academic interest. I have two dear cousins who suffer from a genetic variant that affects their ability to walk among other things. As I understand it, it is a very rare, but not unknown variant. I can't read books like this and not think of them. I also have a number of relatives who very late in life have developed Parkinson's disease. To my knowledge, scientists have not discovered a genetic cause to Parkinson's [...]

    • E. Ce Miller says:

      'The Family Gene' Author Joselin Linder Chronicles The Illness That Killed Seven Of Her RelativesAs even the most seasoned memoirist will tell you, committing one’s family story to print is never easy. When that story involves a potentially-fatal genetic mutation — one that literally has you and other members of your family on a very real deadline — readers can only imagine the urgency of that telling increases exponentially. But this is exactly the kind of story that writer Joselin Linder [...]

    • Serena says:

      In The Family Gene author Joselin Linder, holder of said gene, writes about the experience of discovering her family was passing a variant and ultimately fatal gene through their family tree. After realizing there might be a problem, her family connects with several doctors who become champions for the family and develop years of time researching their new, unnamed condition.The book provides plenty of background information on genetics for the uninitiated, and some interest factoids for those f [...]

    • Jill Meyer says:

      Joselin Linder's book, "The Family Gene: A Mission to Turn My Deadly Inheritance into a Hopeful Future", is a combination science book and coming of age story. Now in her mid-30's, Joselin has seen several members of her father's family - including her father - die from an untreatable disease that also defied classification. The disease was spread among several generations of the Linder family. While working with doctors and geneticists in Boston, a genome was discovered which made testing for t [...]

    • Kelly Abdul says:

      I don't usually read nonfiction, but the inside cover of this seemed so interesting to me and it definitely was. It was almost a murder-mystery because of the author's quest to find out what was killing members of her family. I felt she did a really good job of explaining the medical aspects of this story without talking over your head or condescending to you like you were a complete idiot. My heart goes out to her and her family and I hope that eventually they find definitive answers. I applaud [...]

    • Daryl Binsky says:

      I enjoyed this book. I read it in 3 days. The story was compelling, the author very introspective and the science was presented to me so I could understand it. You are taken through the book much the way the family experienced it, with more information unraveled as you read. A bit like a suspense novel, it really had me turning the pages. I thought the book was very well written and very informative. I learned many things about genetic diseases, potential treatments, and inheritance. But what re [...]

    • Kris Springer says:

      Great combo of medical science and personal family story. Author Joselin Linder's family has a genetic mutation on the X chromosome that affects the lymphatic system, the liver and the spleen. Parts of the book are harrowing, as different family members suffer for years and die very painfully. Yet the author and the book remain positive about the potential of gene therapy to save her and others like her from genetic anomalies and mutations. Every time I read nonfiction like this, I am challenged [...]

    • Janna Dorman says:

      Plagued by a genetic mutation that only affects her family, Joselin Linder writes this memoir about the uncertainty of living with a disease that no doctor can diagnose. Linder does explain a lot of science in here and I didn't always follow, but I'm glad she included as much as she did. I (re)learned a lot about genetics and they are cray. Linder's story still isn't finished as she lives with the disease that killed her great-great grandmother, great-uncle, father, and uncle. So far. If you lik [...]

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